Bokeh server app become slowly after 1 or 2 hours used

When my application is opened, it works very well. But i let it after 1 or 2 hours, it works too slowly.

@DuyNGUYEN There is absolutely nothing that can be said without a complete reproducer that can be run and benchmarked. E.g. as a counterpoint, the Bokeh server that runs at often runs for many months at a time.