Just FYI @Bokeh_coder there are probably better venues to ask Holoviews questions, such as the Pyviz gitter channel (I don’t know the answer to this, e.g.)
The Bokeh Image object does no currently expose any of the canvas interpolation options at the user level. For most scientific/analytical plotting, interpolating an image is specifically the wrong thing to do, so there has never been any priority to make this configurable.
For now you will need to do anything like upscaling and then interpolating as pre-processing, before sending to Bokeh. You can file a GitHub Issue to suggest exposing interpolation as a configurable option but I can’t make any speculation as to when it might be looked at.